The difference between K-Cups and Q-Cups mainly lies in their compatibility with coffee machines and their design: K-Cups: These are plastic pods that contain ground coffee, tea, or hot chocolate. They are specifically designed for Keurig machines and other compatible brewers. K-Cups have a plastic cup with a foil lid and a filter inside1. Q-Cups: These are similar to K-Cups but are designed for use with Hamilton Beach and Cuisinart single-serve coffee machines. Q-Cups also have a plastic cup with a foil lid and a filter inside, but they are not compatible with Keurig machines. Both types of cups offer convenience and a variety of flavors, but they are not interchangeable between different brands of coffee machines.